The Little Sisters of the Sun had caught one group on their mountain and sacrificed the lot, singing the Hymn of Life. Wild bands had eaten another group...
-Leigh Brackett, The Hounds of Skaith
Leigh Brackett can put a lot of horror into a few sentences. The Little Sisters of the Sun, mentioned here in passing, seem sinister enough to deserve their own D&D adventure.
Between the Little Sisters and the wild bands of cannibals, the environment from this passage seems even more dangerous than the average D&D countryside. The wild cannibals puts me in mind of an Oregon Trail journey gone wrong: perhaps my D&D continent has a frontier beyond which there are no patrolled countries or city walls. It's a higher-level zone, perhaps recently re-discovered like Eberron's Xen'drik, and its natives are twisted by post-apocalyptic magic. I assume that the Little Sisters of the Sun were, long ago, neutral good, and the tribes of cannibals are the remnants of civilized feudal peoples.
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