I just recovered from a 24 hour flu. In honor of which, enjoy these plagues.
The Dancing Death: In its first stage, which lasts for weeks, this disease has no effect. In its second stage, which lasts several days, the victim feels energetic and manic, doesn’t sleep very much, and probably seeks out scenes of feasting and celebration. Finally, in the third stage, which lasts about a minute, the victim begins a dance which becomes more spastic and terrifying, and dies. Anyone who sees the dance is infected.
Black Eyed Beauty: Stage one is a minor cold. When you recover, your eye color changes to black. Your charisma is now 18. Even people who know you’re diseased must make a will/wisdom save to leave your presence. During this period, you spread the disease by touch. After a week or two of this, you die, leaving a beautiful corpse.
Brain Fever: Stage one: You are bedridden with a dangerously high fever for three days. You must make a DC10 Con check to survive, with appropriate bonuses if someone is tending you. Stage two: your intelligence and wisdom increase to 22. You can read at 10x speed and have perfect recall. If you’re already working on a project, you become obsessed with its completion. Otherwise you become obsessed with the first project that’s suggested to you. After three days of this, you die. During stage 2, Cure Disease does not work on you. When you die, a small spider crawls out of your mouth. Anyone bitten by the spider must make a DC 12 save or become infected. Evil wizards sometimes harvest these spiders and purposely infect peasants to act as their research assistants.